Ghidella was born in Babinda, in far north Queensland. Her career in television began in the region, as a reporter and presenter for North Queensland Television (now Network Ten). She also produced and presented the regional weekly current affairs program, Newsweek. She moved to Brisbane to work with Network Ten's News division, before going to the Nine Network.

She spent her first three years at the Nine Network reporting for National Nine News, writing and presenting hourly news breaks. In the mid 1990's she began hosting Nine's Daybreak program, which was later renamed National Nine Early News. She took over from Peter Overton as anchor of National Nine Morning News in 2000, but later switched with Mark Ferguson who had taken over at 6am.

Returning to the early news meant she became a regular substitute host on Today filling in for anchor Tracy Grimshaw or newsreader Ian Ross. When Ross left the show in 2002, she became permanent newsreader - the first female morning show newsreader in Australia - and continued as fill in host for the show.

In February 2005, Leila McKinnon replaced Ghidella on Today. Ghidella moved to co-host National Nine Early News alongside Chris Smith and weather presenter Majella Wiemers this lasted until June 2005. Ghidella then moved back to her previous position as news presenter on Today while McKinnon moved to host National Nine Morning News.

Ghidella left Today and the Nine Network on 1 December 2006 with sources claiming she was upset as constantly being overlooked for other roles at National Nine News. Ghidella was replaced by National Nine Morning News presenter Georgie Gardner.

She has hosted events for Qantas, The Australian Grand Prix Corporation, The Sydney Harbour Foreshore Authority, The Special Events Society, Shiseido, The Cairns Business Women's Association, The Cairns Amateurs, The Benevolent Society and ItalCommercio.

She regularly works with Meals on Wheels and is an ambassador for the Variety Clubs of Australia. She is also a supporter of the Humpty Dumpty Foundation and has lent a hand to the Prince of Wales Medical Research Institute and the Hope for the Children Foundation.

She gave birth to her first child Austin Braydon Croll, on 14 April 2007.

In July 2010, Ghidella announced that she is pregnant with her second child, she is due in December.